Proteolytic inactivation of human leukocyte elastase

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1985 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 41, pages 638-640 (issn: 0014-4754, eissn: 1420-9071,

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Authors: R L, Stein; J C, Williams;

doi: 10.1007/bf02007697

pmid: 3846535

Proteolytic inactivation of human leukocyte elastase

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Abstract

Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis. The trypsin-catalyzed inactivation of leukocyte elastase can be slowed by inhibition of trypsin with benzamidine or by occupation of elastase's active site with elastatinal.

Related Organizations

Wilmington University
United States

Keywords

Kinetics, Pancreatic Elastase, Hydrolysis, Leukocytes, Humans, Trypsin, Oligopeptides, Benzamidines

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