Role of phospholipids in the binding activity of vasoactive intestinal peptide receptors
Copyright policy )Role of phospholipids in the binding activity of vasoactive intestinal peptide receptors
Phospholipase digestion of rat intestinal epithelial cell membranes was performed in order to study the influence of membrane phospholipids on the binding activity of VIP receptors. Phospholipases A2 and C strongly (ED50 congruent to 4 X 10(-2) and 4 X 10(-1) micrograms/ml, respectively) and rapidly reduced 125I-VIP binding to membranes whereas phospholipase D was ineffective. This suggests an important role of both hydrophobic and hydrophilic groups of phospholipids on VIP receptor binding activity.
Membrane Lipids, Structure-Activity Relationship, Phospholipases, Animals, Receptors, Vasoactive Intestinal Peptide, Receptors, Cell Surface, Intestinal Mucosa, Phospholipids, Rats, Vasoactive Intestinal Peptide
Membrane Lipids, Structure-Activity Relationship, Phospholipases, Animals, Receptors, Vasoactive Intestinal Peptide, Receptors, Cell Surface, Intestinal Mucosa, Phospholipids, Rats, Vasoactive Intestinal Peptide
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