Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1985 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 41, pages 376-378 (issn: 0014-4754, eissn: 1420-9071,

Copyright policy )

Authors: H, Poiger; C, Schlatter;

doi: 10.1007/bf02004514

pmid: 3972084

Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog

- Summary
- Subjects
- Metrics

Abstract

The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of 3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed 3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 micrograms of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%).

Related Organizations

École Polytechnique Fédérale de Lausanne EPFL
Switzerland
University of Zurich
Switzerland

Keywords

Male, Polychlorinated Dibenzodioxins, Dioxins, Feces, Kinetics, Dogs, Intestinal Absorption, Liver, Phenobarbital, Animals, Bile

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	13
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average