Interferon receptors and their role in interferon action

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1989 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 45, pages 508-513 (issn: 0014-4754, eissn: 1420-9071,

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Authors: S E, Grossberg; J L, Taylor; V M, Kushnaryov;

doi: 10.1007/bf01990499

pmid: 2525482

Interferon receptors and their role in interferon action

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Abstract

Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.

Related Organizations

Medical College of Wisconsin
United States

Keywords

Interferon-gamma, Interferon Type I, Animals, Humans, Cloning, Molecular, Receptors, Immunologic, Models, Biological, Receptors, Interferon

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