Enclomiphene induces luteolysis in the nonpregnant guinea pig

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1989 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 45, pages 104-106 (issn: 0014-4754, eissn: 1420-9071,

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Authors: P K, Westfahl;

doi: 10.1007/bf01990463

pmid: 2492231

Enclomiphene induces luteolysis in the nonpregnant guinea pig

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Abstract

The effect of two antiestrogens, enclomiphene and tamoxifen, on luteal function in the guinea pig was compared to that of estradiol, a known luteolysin. Enclomiphene caused premature luteolysis when administered during the early or mid-luteal phase of the cycle, but was not as potent as estradiol. Tamoxifen had no effect. The luteolytic effect of enclomiphene was mediated by the uterus, as has been shown for estradiol.

Related Organizations

University System of Ohio
United States
Miami University
United States

Keywords

Tamoxifen, Estradiol, Corpus Luteum, Enclomiphene, Guinea Pigs, Animals, Female, Progesterone, Clomiphene

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