Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1983 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 39, pages 891-892 (issn: 0014-4754, eissn: 1420-9071,

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Authors: M A, Crampton; L J, Rogers;

doi: 10.1007/bf01990423

pmid: 6873244

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

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Abstract

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.

Related Organizations

Monash University
Australia
Monash University, Clayton campus
Australia

Keywords

Behavior, Animal, 2,4,5-Trichlorophenoxyacetic Acid, Motor Activity, Rats, Teratogens, Pregnancy, Exploratory Behavior, Animals, Humans, Female

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