Guanabenz as inhibitor of copper-containing amine oxidases

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1986 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 18, pages 46-48 (issn: 0065-4299, eissn: 1420-908X,

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Authors: G, Banchelli; B, Bertocci; L, Raimondi; G, Soldani; M, Del Tacca; F, Buffoni;

doi: 10.1007/bf01987979

pmid: 3088929

Guanabenz as inhibitor of copper-containing amine oxidases

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Abstract

The effects of guanabenz on some copper containing amine oxidases are described. Guanabenz 'in vitro' inhibits pig plasma benzylamine oxidase with a IC50 M 5.1 +/- 0.8 X 10(-6) M. It also inhibits pig kidney diamine oxidase and rat liver mitochondrial monoamine oxidase at higher concentrations. The significance of this property of guanabenz is discussed.

Related Organizations

University of Pisa
Italy
University of Florence
Italy

Keywords

Oxidoreductases Acting on CH-NH Group Donors, Guanabenz, Monoamine Oxidase Inhibitors, Swine, Kidney, Benzylamine Oxidase, Guanidines, Rats, Microsomes, Liver, Animals, Amine Oxidase (Copper-Containing), Copper

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