Bioavailability of progesterone enhanced by intranasal spraying

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1981 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 37, pages 533-534 (issn: 0014-4754, eissn: 1420-9071,

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Authors: G F, David; C P, Puri; T C, Anand Kumar;

doi: 10.1007/bf01986182

pmid: 7250331

Bioavailability of progesterone enhanced by intranasal spraying

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Abstract

The bioavailability of progesterone (P) in terms of area under time-concentration curve and maximal concentration in the serum and cerebrospinal fluid was studied in adult ovariectomized rhesus monkeys following the administration of P as a nasal spray, i.v. or i.m. injections, nasal or eye drops. The bioavailability of P in both the body fluids was found to be considerably higher following its being sprayed intranasally.

Related Organizations

All India Institute of Medical Sciences
India

Keywords

Kinetics, Animals, Female, Macaca mulatta, Administration, Intranasal, Progesterone

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