descriptionPublicationkeyboard_double_arrow_right Article 01 May 1994 English Publisher:Springer Science and Business Media LLCJournal:European Journal of Pediatrics, volume 153, pages 432-437 (issn: 0340-6199, eissn: 1432-1076,

Authors: V, Schuster; S, Seidenspinner; T, Grimm; W, Kress; S, Zielen; M, Bock; H W, Kreth;

doi: 10.1007/bf01983408 , 10.1007/s004310050169

pmid: 7916289

Molecular genetic haplotype segregation studies in three families with X-linked lymphoproliferative disease

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Abstract

Three families with X-linked lymphoproliferative disease were studied. Affected males clinically presented with severe or fatal infectious mononucleosis, acquired hypogammaglobulinaemia, hypergammaglobulinaemia M, and malignant lymphoma including Hodgkin disease. Haplotype analysis using various DNA markers from Xq25-q27 allowed the prediction of the carrier status in females and identification of the XLP status in asymptomatic males.

Related Organizations

Goethe University Frankfurt
Germany
Boston Children's Hospital
United States
University of Würzburg
Germany

Keywords

Male, Heterozygote, X Chromosome, Base Sequence, Genetic Linkage, Molecular Sequence Data, Polymerase Chain Reaction, Lymphoproliferative Disorders, Pedigree, Haplotypes, Humans, Female, Polymorphism, Restriction Fragment Length

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