T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1986 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 19, pages 256-265 (issn: 0065-4299, eissn: 1420-908X,

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Authors: C, Linington; H, Wekerle; R, Meyermann;

doi: 10.1007/bf01971223

pmid: 2435116

T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

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Abstract

Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barre syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.

Keywords

T-Lymphocytes, Myelin Basic Protein, Rats, Inbred Strains, Neuritis, Autoimmune, Experimental, Autoimmune Diseases, Cell Line, Rats, Animals, Schwann Cells, Myelin Sheath

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