Histamine release by platelet aggregation
Copyright policy )Histamine release by platelet aggregation
Coincubation of rat serosal mast cells with human platelets leads to a significant release of histamine. which dose-dependently increases when platelet aggregation is induced by various concentrations of arachidonic acid. In turn, histamine enhances platelet aggregation induced by different agonists, this effect being mimicked by pyridyl-ethyl-amine (PEA), blocked by mepyramine and amplified by ranitidine. The data suggest the existence of a platelet-derived histamine releasing factor (PDHRF) and indicate the presence of platelet H1 and H2 receptors, capable of modulating platelet aggregation.
- New York University Italy
- University of Florence Italy
Blood Platelets, Male, Pyrilamine, L-Lactate Dehydrogenase, Platelet Aggregation, Pyridines, Rats, Inbred Strains, Arachidonic Acids, In Vitro Techniques, Ranitidine, Histamine Release, Rats, Animals, Mast Cells
Blood Platelets, Male, Pyrilamine, L-Lactate Dehydrogenase, Platelet Aggregation, Pyridines, Rats, Inbred Strains, Arachidonic Acids, In Vitro Techniques, Ranitidine, Histamine Release, Rats, Animals, Mast Cells
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