Inhibition of diamine oxidase by antimalarial drugs

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1980 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 10, pages 395-398 (issn: 0065-4299, eissn: 1420-908X,

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Authors: K, Ma; T L, Sourkes;

doi: 10.1007/bf01968035

pmid: 6782842

Inhibition of diamine oxidase by antimalarial drugs

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Abstract

The antimalarial drugs amodiaquine, quinacrine and chloroquine inhibit the catabolism of putrescine by the rat. Amodiaquine, the most potent of the three, does so in a dose-dependent fashion. This is attributed to the action in vivo of the drugs on diamine oxidase, an enzyme that is inhibited by them in vitro.

Related Organizations

McGill University
Canada

Keywords

Male, Amodiaquine, Chloroquine, In Vitro Techniques, Rats, Antimalarials, Quinacrine, Intestine, Small, Putrescine, Animals, Amine Oxidase (Copper-Containing)

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