Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1987 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 21, pages 278-280 (issn: 0065-4299, eissn: 1420-908X,

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Authors: M A, Iannone; G, Wolberg; R, Reynolds-Vaughn; T P, Zimmerman;

doi: 10.1007/bf01966490

pmid: 2891263

Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding

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Abstract

We have studied the effect of taxol on two N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced neutrophil functions and the possible mechanism by which it inhibits these functions. Taxol inhibited FMLP-induced human neutrophil polarization (a characteristic change in neutrophil shape in response to a chemotactic stimulus) and H2O2 generation. Taxol also decreased the specific binding of [3H]FMLP to human neutrophils at 4 degrees C. The decreased binding of FMLP to its receptor may be responsible for the inhibition by taxol of FMLP-induced polarization and H2O2 generation.

Related Organizations

Research Triangle Park Foundation
United States

Keywords

N-Formylmethionine Leucyl-Phenylalanine, Kinetics, Alkaloids, Binding Sites, Paclitaxel, Neutrophils, Humans, Hydrogen Peroxide, In Vitro Techniques

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