Resistance to ethidium bromide inAspergillus nidulans

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1979 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 35, pages 307-308 (issn: 0014-4754, eissn: 1420-9071,

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Authors: M. E. Scarazzatti; R. Bonatelli; J. L. Azevedo;

doi: 10.1007/bf01964316

Resistance to ethidium bromide inAspergillus nidulans

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Abstract

A mutant ofAspergillus nidulans resistant to ethidium bromide was isolated and the semi-dominant gene responsible for this resistance was allocated on linkage group II at 17.42±3.05 units of recombination from thewA3 gene. The gene also confers cross-resistance to acriflavin, malachite green and crystal violet. It was also shown that riboflavin is antagonistic to the toxic effect of ethidium bromide, at certain concentrations. The mechanisms which could be responsible for the toxic effect of this drug are discussed and compared with those of acriflavin. The use of theEtb1 gene in genetical analysis through the parasexual cycle is suggested.

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State University of Campinas
Brazil

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