Tumorigenic potential of endoperoxide analogs
Copyright policy )Tumorigenic potential of endoperoxide analogs
The endoperoxide analogs known as U-46619 and U-44069 significantly enhanced the carcinoma formation and cellular atypicality initiated by a chemical carcinogen in mice. Studies of DNA radioactivity demonstrated that endoperoxides exerted their cocarcinogenic action by stimulating DNA synthesis. Thus, they play an important role in tumor cell proliferation.
- Wayne State University United States
- Wayne State College United States
DNA Replication, Male, Cocarcinogenesis, Prostaglandin Endoperoxides, Synthetic, Mice, Microscopy, Electron, Cell Transformation, Neoplastic, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Carcinoma, Squamous Cell, Animals, Methylcholanthrene
DNA Replication, Male, Cocarcinogenesis, Prostaglandin Endoperoxides, Synthetic, Mice, Microscopy, Electron, Cell Transformation, Neoplastic, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Carcinoma, Squamous Cell, Animals, Methylcholanthrene
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