α-Amanitin: Inactivation by bovine lactoperoxidase

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1979 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 35, pages 589-591 (issn: 0014-4754, eissn: 1420-9071,

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Authors: P W, Morris; K M, Kelley; W G, Logas;

doi: 10.1007/bf01960335

pmid: 109306

α-Amanitin: Inactivation by bovine lactoperoxidase

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Abstract

The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.

Related Organizations

University of Illinois System
United States
University of Illinois at Urbana–Champaign
United States

Keywords

Amanitins, Drosophila melanogaster, Time Factors, Peroxidases, Animals, Cattle, Lactoperoxidase, RNA Polymerase II, In Vitro Techniques

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