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Angiotensin converting enzyme inhibitors

Name: Angiotensin converting enzyme inhibitors
Creator: W. Soudijn
Keywords: 03 medical and health sciences, Captopril, 0302 clinical medicine, Chemical Phenomena, Chemistry, Physical, Animals, Angiotensin-Converting Enzyme Inhibitors, Stereoisomerism, Rabbits, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1982 English Publisher:Springer Science and Business Media LLCJournal:Pharmaceutisch Weekblad Scientific Edition, volume 4, pages 154-158 (issn: 0167-6555, eissn: 1573-739X,

Authors: W. Soudijn;

doi: 10.1007/bf01959035

pmid: 6292819

Angiotensin converting enzyme inhibitors

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Abstract

Inhibition of angiotensin converting enzyme (ACE) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally active ACE inhibitor and the structure-activity relationship of captopril analogues are described. Some side effects of captopril were attributed to the presence of an SH-group in the molecule. This led to the development of a series of non-mercapto ACE inhibitors derived from captopril. One of them, enalapril, a potent ACE inhibitor with a long duration of antihypertensive action, is now tested in clinical trials.

Related Organizations

University of Amsterdam
Netherlands

Keywords

Captopril, Chemical Phenomena, Chemistry, Physical, Animals, Angiotensin-Converting Enzyme Inhibitors, Stereoisomerism, Rabbits

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