Two novel prolactin release-inhibiting 8α-amino-ergolines

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1979 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 35, pages 1,677-1,678 (issn: 0014-4754, eissn: 1420-9071,

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Authors: E, Flückiger; U, Briner; H R, Bürki; P, Marbach; H R, Wagner; W, Doepfner;

doi: 10.1007/bf01953267

pmid: 520501

Two novel prolactin release-inhibiting 8α-amino-ergolines

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Abstract

Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.

Keywords

Dopamine, Corpus Striatum, Prolactin, Rats, Structure-Activity Relationship, Pregnancy, 3,4-Dihydroxyphenylacetic Acid, Animals, Lactation, Female, Embryo Implantation, Ergolines

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Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines
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