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Further characterization of sulfated homopolysaccharides as anti-HIV agents

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1989Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 45, pages 996-998 (issn: 0014-4754, eissn: 1420-9071,

Authors: W. Itoh; K. Shimada; Satoshi Kimura; Isamu Sugawara; Shigeo Mori;

doi: 10.1007/bf01953060

pmid: 2478388

Further characterization of sulfated homopolysaccharides as anti-HIV agents

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Abstract

Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (AZT).

Related Organizations

Institute of Medical Sciences
India
University of Tokyo
Japan

Keywords

Acquired Immunodeficiency Syndrome, Dextran Sulfate, HIV, Dextrans, Drug Synergism, Antiviral Agents, Polysaccharides, Leukocytes, Mononuclear, Humans, Reverse Transcriptase Inhibitors, Zidovudine

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	49
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%