Degradation of [3H]thymidine by a pentosyltransferase (EC 2.4.2.4) in the plasma of man and different animals

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1977 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 33, pages 668-670 (issn: 0014-4754, eissn: 1420-9071,

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Authors: J L, Pauly; M G, Schuller; A A, Zelcer; M J, Germain;

doi: 10.1007/bf01946565

pmid: 266473

Degradation of [3H]thymidine by a pentosyltransferase (EC 2.4.2.4) in the plasma of man and different animals

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Abstract

[3H]Thymidine is degraded by an enzyme (thymidine phosphorylase; EC 2.4.2.4) which we have identified in the plasma of man and some animals. The presence of this enzyme in plasma or sera used to supplement culture media may, under certain experimental conditions, limit the validity of measuring the uptake of radiolabeled thymidine as a means of defining DNA synthesis.

Related Organizations

New York State Department of Health
United States

Keywords

Male, Thymidine Phosphorylase, DNA, Kinetics, Species Specificity, Leukemia, Myeloid, Animals, Humans, Female, Pentosyltransferases, Thymidine

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