descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1973 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 29, pages 1,473-1,474 (issn: 0014-4754, eissn: 1420-9071,

Authors: R. Faluotico; G. Perez;

doi: 10.1007/bf01943863

pmid: 4772033

Creatinine: A precursor of methylguanidine

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Abstract

Intraperitoneale Zufuhr von14CH3-Kreatinin in Ratten erhoht deren 24-h-Ausscheidung von radiomarkiertem Methyl-Guanidin im Urin, wahrend Tiere, die andere radiomarkierte potentielle Vorlaufer erhalten hatten, keine erhohte Ausscheidung zeigten. Diese in-vivo-Konversion von Kreatinin zu Methyl-Guanidin konnte nicht der Aktion gastrointestinaler Bakterien zugeschrieben werden, da die Ausscheidung von Methyl-Guanidin sowohl in antibiotikabehandelten als auch in sterilen Ratten ubereinstimmte.

Related Organizations

Miami University
United States
Larue Carter Hospital
United States

Keywords

Nystatin, Sulfadiazine, Neomycin, Tetracycline, Arginine, Chromatography, Ion Exchange, Guanidines, Rats, Creatinine, Animals, Autoradiography, Urea, Carbon Radioisotopes

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