An antiviral factor fromMelia azedarach L. prevents Tacaribe virus encephalitis in mice
Copyright policy )An antiviral factor fromMelia azedarach L. prevents Tacaribe virus encephalitis in mice
Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azedarach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures.
- Facultad de Ciencias Agrarias y Forestales Argentina
- University of Buenos Aires Argentina
Plant Extracts, Virus Replication, Antiviral Agents, Hemorrhagic Fever, American, Mice, Animals, Newborn, Pregnancy, Animals, Encephalitis, Lactation, Female, Arenaviruses, New World
Plant Extracts, Virus Replication, Antiviral Agents, Hemorrhagic Fever, American, Mice, Animals, Newborn, Pregnancy, Animals, Encephalitis, Lactation, Female, Arenaviruses, New World
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