Inactivation of sarin and soman by cyclodextrins in vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1987 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 43, pages 395-397 (issn: 0014-4754, eissn: 1420-9071,

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Authors: B, Désiré; S, Saint-André;

doi: 10.1007/bf01940424

pmid: 3569488

Inactivation of sarin and soman by cyclodextrins in vitro

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Abstract

Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.

Keywords

Cyclodextrins, alpha-Cyclodextrins, Soman, beta-Cyclodextrins, Organothiophosphorus Compounds, Starch, Sarin, Organophosphates, Kinetics, Organophosphorus Compounds, Dextrins, gamma-Cyclodextrins

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