Restriction fragment length polymorphisms in theETS-1 proto-oncogene Comparison of Saudi and Western populations

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1988 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 44, pages 1,019-1,020 (issn: 0014-4754, eissn: 1420-9071,

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Authors: M H, Parkar; J M, Seid; J M, Rowson; B M, Stringer; L J, Vencer; R J, Aur; M H, Goyns;

doi: 10.1007/bf01939909

pmid: 2461869

Restriction fragment length polymorphisms in theETS-1 proto-oncogene Comparison of Saudi and Western populations

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Abstract

We have cloned part of the ETS 1 proto-oncogene and demonstrated the presence of two polymorphic Sst I restriction sites. A probe derived from one of our clones revealed the presence of 8.3 kb, 9.5 kb and/or 11.5 kb fragments on Southern blots of human DNA samples. The relative frequencies of these alleles appear to be significantly different between Saudi and Western populations, but there are no apparent differences in these frequencies between Saudi non-leukemic and leukemic individuals.

Related Organizations

King Faisal Specialist Hospital & Research Centre
Saudi Arabia

Keywords

Polymorphism, Genetic, Proto-Oncogene Proteins c-ets, Saudi Arabia, Nucleic Acid Hybridization, DNA, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Mas, Europe, Proto-Oncogene Protein c-ets-1, Blotting, Southern, Gene Frequency, Proto-Oncogene Proteins, Proto-Oncogenes, Humans, Americas, Alleles, Polymorphism, Restriction Fragment Length, Transcription Factors

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