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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Cellular and Molecul...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Cellular and Molecular Life Sciences
Article . 1977 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 1977
Data sources: Europe PubMed Central
https://dx.doi.org/10.1007/bf0...
Article
Data sources: Microsoft Academic Graph
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Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1977 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 33, pages 484-485 (issn: 0014-4754, eissn: 1420-9071, Copyright policy )
Authors: J, Pachecka; M, Salmona; G, Belvedere; L, Cantoni; E, Mussini; S, Garattini;

doi: 10.1007/bf01922224

pmid: 862740

Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide

Abstract

Cyproheptadine epoxide is a competitive inhibitor or rat liver microsomal epoxide hydrase with an apparent K1-value of 0.75 mM. Cyclobenzaprine and its epoxide stimulate in vitro the activity of this enzyme, whereas cyproheptadine, carbamazepine and carbamazepine epoxide have no effect.

Related Organizations
Keywords

Epoxide Hydrolases, Kinetics, Structure-Activity Relationship, Carbamazepine, Cyproheptadine, Microsomes, Liver, Hydro-Lyases

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    popularity
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Average
Average
Average
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