Mitogenicity of autolysates ofTrypanosoma congolense

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 34, pages 127-129 (issn: 0014-4754, eissn: 1420-9071,

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Authors: R K, Assoku; I R, Tizard;

doi: 10.1007/bf01921943

pmid: 620724

Mitogenicity of autolysates ofTrypanosoma congolense

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Abstract

Autolysates of Trypanosoma congolense, in subcytotoxic amounts, were found to be highly mitogenic in vitro for the spleen cells of normal mice. Significant amounts of [3H]-thymidine were also incorporated by the responding spleen cells of nu/nu (athymic) mice. In contrast, the spleen cells of cyclophosphamide-treated mice were unresponsive. The findings suggest that a potent B-cell-mitogen is generated by the autolysing T. congolense organism.

Related Organizations

University of Guelph
Canada

Keywords

Mice, Trypanosoma, Animals, In Vitro Techniques, Mitogens, Autolysis, Cyclophosphamide, Spleen

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