Cl−/HCO 3 − exchanger is operative in isolated enterocytes from rat jejunum

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1996 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 52, pages 245-248 (issn: 0014-4754, eissn: 1420-9071,

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Authors: M, Tosco; M N, Orsenigo; A, Faelli;

doi: 10.1007/bf01920716

pmid: 8631395

Cl−/HCO 3 − exchanger is operative in isolated enterocytes from rat jejunum

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Abstract

Enterocytes isolated from rat jejunum were tested for the existence of a Cl-/HCO(-3) exchange, previously evidenced in basolateral membrane vesicles but not in brush border. Cells were found to retain functional integrity and transport capabilities long enough to allow Cl- fluxes to be measured. Both efflux and uptake experiments indicate that a Cl-/HCO(-3) antiport, inhibited by 4,4'-diisothiocyanostilbene-2-2'-disulfonic acid (DIDS), is functional under resting conditions.

Related Organizations

University of Milan
Italy

Keywords

Male, Cell Survival, Biological Transport, Hydrogen-Ion Concentration, Antiporters, Rats, Bicarbonates, Jejunum, Chlorides, Animals, Chloride-Bicarbonate Antiporters, Rats, Wistar, Cells, Cultured

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