Lymphopenia and lymphocyte transformation in alcoholics

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1979 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 35, pages 268-269 (issn: 0014-4754, eissn: 1420-9071,

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Authors: G P, Young; M B, Van der Weyden; I S, Rose; F J, Dudley;

doi: 10.1007/bf01920656

pmid: 421856

Lymphopenia and lymphocyte transformation in alcoholics

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Abstract

The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.

Related Organizations

Monash University
Australia
The Alfred Hospital
Australia

Keywords

Immunosuppression Therapy, Alcoholism, Pokeweed Mitogens, Lymphopenia, Humans, Phytohemagglutinins, Lymphocyte Activation

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