Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1977 English Publisher:Springer Science and Business Media LLCJournal:Experientia, volume 33, pages 1,516-1,518 (issn: 0014-4754, eissn: 1420-9071,

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Authors: D V, Singh; R L, Campbell; Y N, Lin; N D, Nigro;

doi: 10.1007/bf01918844

pmid: 923732

Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats

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Abstract

Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acids as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the concentration of fecal bile acids and neutral steroids.

Related Organizations

Wayne State College
United States

Keywords

Male, Azoxymethane, Adenocarcinoma, Rats, Bile Acids and Salts, Feces, Propylthiouracil, Intestinal Neoplasms, Animals, Steroids, Azo Compounds

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