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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Cellular and Molecul...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Cellular and Molecular Life Sciences
Article . 1972 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Stabilization of mouse brain glutamic decarboxylase

Authors: E, Roberts; M, Szabo; B, Haber;

Stabilization of mouse brain glutamic decarboxylase

Abstract

Le GAD du cerveau de souris, une enzyme sensible au SH, peut etre purifie en presence de 2-aminoethyl-isothiouronium-bromide (AET), une substance radioprotective. AET, qui existe en solution neutre, comme 2-mercaptoethyl guanidine, protege les enzymes qui contiennent le SH bien mieux que les quantites isomolares du GSH ou du dithioerythretol (Cleland's reagent). En outre, il est possible que l'AET soit une source naissante de mercaptoethylamine qui produit un derivatif de thiazolidine avec le groupe aldehyde de pyridoxal phosphate qui opere independamment comme galeyeur. Ce mecanisme explique la qualite radioprotective superieure de l'AET et des aminothiols in vivo en comparaison des substances qui ne contiennent pas d'amino.

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Keywords

Carbon Isotopes, Photolysis, Carboxy-Lyases, Ultraviolet Rays, Brain, Radiation-Protective Agents, Glutathione, Radiation Effects, Dithiothreitol, Mice, Glutamates, Pyridoxal Phosphate, Animals, beta-Aminoethyl Isothiourea

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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