
doi: 10.1007/bf01918639
pmid: 4665282
Le GAD du cerveau de souris, une enzyme sensible au SH, peut etre purifie en presence de 2-aminoethyl-isothiouronium-bromide (AET), une substance radioprotective. AET, qui existe en solution neutre, comme 2-mercaptoethyl guanidine, protege les enzymes qui contiennent le SH bien mieux que les quantites isomolares du GSH ou du dithioerythretol (Cleland's reagent). En outre, il est possible que l'AET soit une source naissante de mercaptoethylamine qui produit un derivatif de thiazolidine avec le groupe aldehyde de pyridoxal phosphate qui opere independamment comme galeyeur. Ce mecanisme explique la qualite radioprotective superieure de l'AET et des aminothiols in vivo en comparaison des substances qui ne contiennent pas d'amino.
Carbon Isotopes, Photolysis, Carboxy-Lyases, Ultraviolet Rays, Brain, Radiation-Protective Agents, Glutathione, Radiation Effects, Dithiothreitol, Mice, Glutamates, Pyridoxal Phosphate, Animals, beta-Aminoethyl Isothiourea
Carbon Isotopes, Photolysis, Carboxy-Lyases, Ultraviolet Rays, Brain, Radiation-Protective Agents, Glutathione, Radiation Effects, Dithiothreitol, Mice, Glutamates, Pyridoxal Phosphate, Animals, beta-Aminoethyl Isothiourea
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