Ro (SSA) and La (SSB) antibodies

descriptionPublicationkeyboard_double_arrow_right Article , Part of book or chapter of book 01 Sep 1981 English Publisher:Springer Science and Business Media LLCJournal:Springer Seminars in Immunopathology, volume 4, pages 253-273 (issn: 0344-4325, eissn: 1432-2196,

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Authors: E L, Alexander; T T, Provost;

doi: 10.1007/bf01892181 , 10.1007/978-3-642-68702-0_12

pmid: 7041301

Ro (SSA) and La (SSB) antibodies

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Abstract

This review traces the historical development of information regarding the Ro (SSA) and La (SSB) autoantibody systems over the past twenty years. Clinical and serologic findings are integrated with fundamental observations in this rapidly expanding area of research. Retrospective analysis of the physicochemical properties of the antigens and the cellular staining characteristics of antibodies to these antigens suggest that SjD and Ro and SSA, as well as SjT and La, SSB, and Ha antigens probably are similar macromolecules. The immunologic identity of Ro with SSA and La with SSB and Ha has been established previously. Antibodies to these antigens are directed against macromolecules containing small RNA nucleotides.

Related Organizations

Johns Hopkins Medicine
United States
JOHNS HOPKINS UNIVERSITY
United States

Keywords

Lupus Vulgaris, Nephritis, Myositis, Antigen-Antibody Complex, Complement System Proteins, Phenotype, Sjogren's Syndrome, Antibody Specificity, Central Nervous System Diseases, HLA Antigens, Antibodies, Antinuclear, Humans, Lupus Erythematosus, Systemic, Autoantibodies

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