Inhibition of tumor cell growth by a human B-cell line

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1994 English Publisher:Springer Science and Business Media LLCJournal:Biotherapy, volume 8, pages 1-6 (issn: 0921-299X, eissn: 1573-8280,

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Authors: M, Katano; E, Kubota; F, Nagumo; T, Matsuo; T, Hisatsugu; J, Tadano;

doi: 10.1007/bf01878115

pmid: 7547076

Inhibition of tumor cell growth by a human B-cell line

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Abstract

An Adenocarcinoma cell line (Breast-M) and an Epstein-Barr virus (EBV)-infected B-cell line (Hairy-BM) were established from breast tumor tissue. The Hairy-BM was CD20+, CD25 (Tac)+ and surface immunoglobulin (sIg)+. Hairy-BM suppressed the in vitro proliferation of Breast-M in a time- and a dose-dependent manner. The suppression was also found in 5 different human tumor targets showing tumor-Hairy-BM binding, but not; in 2 murine tumor targets showing no significant tumor-Hairy-BM binding. Lytic activity of Hairy-BM was found only against Breast-M.

Related Organizations

Saga Group
United Kingdom
Saga Medical School Hospital
Japan

Keywords

B-Lymphocytes, Herpesvirus 4, Human, Immunity, Cellular, Leukemia, Hairy Cell, Cell Survival, Receptors, Antigen, B-Cell, Tetrazolium Salts, Breast Neoplasms, Receptors, Interleukin-2, Adenocarcinoma, Antigens, CD20, Polymerase Chain Reaction, Thiazoles, Lymphocytes, Tumor-Infiltrating, Tumor Cells, Cultured, Humans, Coloring Agents, Killer Cells, Lymphokine-Activated

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