Haemodialysis in rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1978 English Publisher:Springer Science and Business Media LLCJournal:Research in Experimental Medicine, volume 172, pages 187-191 (issn: 0300-9130, eissn: 1433-8580,

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Authors: A, Röckel; A, Brand; A, Stanjek; G, Hevendehl; A, Heidland; J, Hoeltzenbein; F S, Pedersen;

doi: 10.1007/bf01851410

pmid: 644141

Haemodialysis in rats

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Abstract

A plate dialyser requiring an extracorporeal blood volume of 1.5 ml was developed to dialyse conscious rats. In experiments in vitro and in vivo its function was tested. The in vitro clearances of urea, creatinine and potassium were 126+/-9 ml/min/m2, 70.5+/-9 ml/min/m2, and 132.5+/-13 ml/min/m2, respectively. The method appears to be suitable for pharmacological and toxicological studies.

Keywords

Creatinine, Animals, Urea, Female, Kidneys, Artificial, Rats

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