A new image processing procedure enabling the automatic detection of coronary artery stenoses by cineangiography was developed. Detection of stenoses was performed using computer image processing by the following procedure. The path of the arteries was extracted by a subtraction method. The thresholding image was obtained from the subtraction image, and converted to a 'thinning' image, which represented the center line of the artery. For measurement of the arterial diameter, the vessel edges were determined by unilateral Gaussian fit to profile curves in sections perpendicular to the center line. Stenoses could then be detected on the basis of the normal diameter of artery estimated by Hough transformation. This method facilitates the detection of stenotic lesions from coronary cineangiograms.