Study of double and triple simultaneous substitutions of amino acids in cytochromes C
Copyright policy )Study of double and triple simultaneous substitutions of amino acids in cytochromes C
A statistical analysis aimed at obtaining some informations on a possible correlation between simultaneous amino acid substitutions is proposed. This method is applied to a set of cytochrome C, at the level of tandem and triple substitutions separated along the peptide chain by 1 to 15 peptide bonds. Monte-Carlo simulations are performed and the results are compared. We find a significant occurrence of three adjacent amino acid substitutions in which the first replacement requires a two nucleotide substitution. A possible explanation of this fact is proposed on the basis of covarions.
- Université Libre de Bruxelles Belgium
Ecologie, Biologie moléculaire, Cytochrome c Group, Evolution des espèces, Plants, Biological Evolution, Models, Biological, Genetic Code, Animals, Amino Acid Sequence, Biologie
Ecologie, Biologie moléculaire, Cytochrome c Group, Evolution des espèces, Plants, Biological Evolution, Models, Biological, Genetic Code, Animals, Amino Acid Sequence, Biologie
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