Vaccine efficacy of recombinant feline herpesvirus type 1 expressing immunogenic proteins of feline calicivirus in cats

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1996 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 141, pages 2,339-2,351 (issn: 0304-8608, eissn: 1432-8798,

Copyright policy )

Authors: N, Yokoyama; K, Maeda; K, Fujita; S, Ishiguro; T, Sagawa; M, Mochizuki; Y, Tohya; +1 Authors

doi: 10.1007/bf01718635

pmid: 9526541

Vaccine efficacy of recombinant feline herpesvirus type 1 expressing immunogenic proteins of feline calicivirus in cats

- Summary
- Subjects
- Metrics

Abstract

We previously constructed a recombinant feline herpesvirus type 1 (FHV1), C7301dlTK-Cap, which contains an entire open reading frame encoding the capsid protein of feline calicivirus (FCV) F4 strain in the deleted locus of the thymidine kinase (TK) deficient mutant (C7301dlTK) of FHV1. In this report, we carried out in vivo experiments to assess the vaccine efficacy of the recombinant C7301dlTK-Cap against FCV and FHV1 infections in cats. As a result, two vaccinations with the C7301dlTK-Cap by intraocular, intranasal and oral routes protected cats to a significant degree against subsequent virulent challenges with both parent FCV F4 and FHV1 C7301 strains. The results are applicable for the further development of a new genetically engineered polyvalent vaccine for cats.

Related Organizations

University of Tokyo
Japan
Kagoshima University
Japan

Keywords

Vaccines, Synthetic, Administration, Oral, Viral Vaccines, Herpesviridae Infections, Antibodies, Viral, Thymidine Kinase, Recombinant Proteins, Capsid, Neutralization Tests, Cats, Animals, Administration, Intranasal, Cells, Cultured, Herpesviridae, Caliciviridae Infections, Calicivirus, Feline

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%