Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase
Copyright policy )Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase
The DNA sequence of an open reading frame (ORF) corresponding to the canine adenovirus type 1 (Can1) proteinase gene was determined. A total of 1171 base pairs were sequenced from the downstream end of the HindIII-A Can1 genomic fragment, including adjacent regions corresponding to the carboxy-terminal portions of the hexon and the DNA-binding proteins. The predicted Can1 proteinase consists of 206 residues (23,325 D) of which 68% are identical and 83% are similar to the sequence of the human Ad2 proteinase. Alignment with the Ad2 proteinase identified a number of conserved residues that could form part of the catalytic triad of the enzyme.
Cysteine Endopeptidases, Dogs, Base Sequence, Sequence Homology, Amino Acid, DNA, Viral, Molecular Sequence Data, Animals, Amino Acid Sequence, Adenoviridae
Cysteine Endopeptidases, Dogs, Base Sequence, Sequence Homology, Amino Acid, DNA, Viral, Molecular Sequence Data, Animals, Amino Acid Sequence, Adenoviridae
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