Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1977 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Environmental Contamination and Toxicology, volume 17, pages 447-455 (issn: 0007-4861, eissn: 1432-0800,

Copyright policy )

Authors: J, Chmielnicka; I, Balcerska; A, Pietruszczak; E, Brzeznicka;

doi: 10.1007/bf01685937

pmid: 861398

Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds

- Summary
- Subjects
- Metrics

Abstract

In course of prolonged exposure [14 weeks] to various mercury compounds [MetHg - a fluid seed-dressing preparation 0,8. Phenyl and Ethyl chlorides and HgC1(2) in doses corresponding to 5% of DL(50)[3 times weekly], enhanced levels of activity of malate dehydrogenase [MDH] and glucosephosphate isomerase [PHI] in blood serum were observed. After 7 weeks of exposure about fourfold increase of MDH and 2-3-fold enhancement of PHI activities were found relative to controls. After 14 weeks of exposure in livers of rats, given MetHg and EtHg, organic mercury was found at concentrations of 28.8 and 4 microng/g tissue, respectively. Inorganic mercury in liver was found in animals given all coumpounds and concentrations were in the range of 1,2 - 4,7 microng/g tissue.

Related Organizations

Institute for Environmental Research
Iran (Islamic Republic of)

Keywords

Erythrocytes, Time Factors, Organomercury Compounds, Glucose-6-Phosphate Isomerase, Mercury, Organ Size, Stimulation, Chemical, Rats, Glutathione Reductase, Liver, Malate Dehydrogenase, Animals, Female

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	2
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average