AbstractPercutaneous fine‐needle aspiration biopsy is a relatively simple invasive procedure with good patient acceptance, low morbidity, and almost negligible mortality. It provides a diagnosis of pulmonary, hilar, and mediastinal masses quickly and accurately, thus eliminating many laboratory tests, saving hospital days, and thereby saving time and money. Percutaneous One‐needle aspiration biopsy should be performed early in the investigation of many types of intrathoracic lesions.