AbstractFifty partial hepatectomies were performed in 49 patients as the definitive treatment for symptomatic intrahepatic stones. The part of the liver containing the strictured ducts and stones was resected. In 39 patients, it was done as the primary procedure, and in 11, it was done when an initial procedure (including one left hepatic lobectomy) had failed. Partial hepatectomy was the preferred method of management when the patients had 1 or more of the following conditions: stones confined to one segment or one lobe of the liver; destruction of the portion of the liver harboring the stones from repeated episodes of obstruction and infection; and multiple strictures of the ducts in the involved portion of the liver. The operative mortality was 2%. Long‐term follow‐up on 44 patients at a median of 7 years showed that 82% were symptom free, 7% had occasional mild attacks of cholangitis, and 11% had severe cholangitis requiring surgical intervention. At reoperation for severe cholangitis, 2 were found to have sphincteroplasty strictures and 3 had stones and ductal strictures. The low operative mortality rate and the overall good results show that partial hepatectomy can be considered as the primary treatment of choice for selected patients with intrahepatic stones.