AbstractSplenic abscess is an unusual disease and may be present either as a localized area of infection in the spleen or as a part of generalized sepsis. There are no specific clinical findings for a splenic abscess; the symptoms and signs of sepsis should arouse a suspicion of splenic abscess. Computerized axial tomography (CAT) scan probably offers the most direct way of evaluating the spleen and making an early diagnosis. Although gram‐positive cocci are most frequently reported in splenic abscesses, there is enough variation of organisms that specific combination of antibiotics cannot be recommended. Antibiotic selection should be based on positive blood cultures and intraoperative cultures. The preferred treatment is splenectomy, although occasionally external drainage may be required. A successful outcome is dependent on an early diagnosis and prompt treatment by splenectomy. When splenic abscess is part of an overall septic process, the prognosis is generally very poor.