Ag-NOR protein distribution correlates with patient survival in stage I endometrial adenocarcinoma

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1992 English Publisher:Springer Science and Business Media LLCJournal:Virchows Archiv A Pathological Anatomy and Histopathology, volume 421, pages 203-207 (issn: 0174-7398, eissn: 1432-2307,

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Authors: D, Trerè; A, Cancellieri; A, Perrone; G, Rocchetta; G, Pelusi; V, Eusebi; M, Derenzini;

doi: 10.1007/bf01611176

pmid: 1413487

Ag-NOR protein distribution correlates with patient survival in stage I endometrial adenocarcinoma

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Abstract

The relationship between argyrophil nucleolar organizer region (Ag-NOR) protein quantity and prognosis was studied in 33 cases of stage I endometrial adenocarcinoma. Ag-NOR protein quantity was measured by image analysis in silver-stained sections from paraffin-embedded samples of curettings. Patients had a minimum 10-year follow-up. Only 2 out of 25 patients exhibiting a mean Ag-NOR protein area of less than 3 microns2 died of cancer, whereas 5 of the 8 patients with a mean Ag-NOR protein area of more than 3 microns2 died of the disease. The present results demonstrate that the Ag-NOR protein value is closely related to patient survival in stage I endometrial carcinoma and that it is a reliable prognostic indicator in this type of carcinoma.

Related Organizations

Alma Mater Studiorum University of Bologna
Italy
Ospedale Bellaria
Italy
Azienda USL di Bologna
Italy

Keywords

Adult, Nuclear Proteins, Antigens, Nuclear, Adenocarcinoma, Middle Aged, Prognosis, Endometrial Neoplasms, Survival Rate, Image Processing, Computer-Assisted, Humans, Female, Aged, Follow-Up Studies

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