This paper presents a general overview of strategies relevant to strengthen the network potential of Swedish medium-sized cities. In several respects, these cities have reached dominant positions in their regional framework. In the emerging network economy, industrial firms and service institutions become increasingly exposed to competition, not only within the national framework but also in the international context. Several medium-sized cities in Sweden are in a vulnerable position. They are in need of the development of new types of strategies. The most vital aspects are to develop an entrepreneurial urban governance, to strengthen import links which promote new specialization efforts, to establish strategic alliances with other cities, and to finance the renewal of infrastructure.