Pregnancy raises insulin requirement, lowers the renal threshold for glucose, increases the tendency to infection of the urinary tract and to renal insufficiency. Diabetic women are more prone to hydramnios, toxemia, stillbirths and neonatal deaths. Their infants, in contrast to their appearance (macrosomia), are immature and of low vitality. Congenital abnormalities, hyaline membrane disease, cardiac dilatation, hyperbilirubinemia, hypocalcemic tetany make their adaptation to extrauterine life difficult during the first few days. Good cooperation between internist, obstetrician, anesthesiologist and pediatrician considerably improves the prognosis of diabetic pregnancies.