The association between emotion and gastrointestinal dysfunction has been postulated for centuries, and all practicing clinicians have anecdotal experience of the association between stress and irritable bowel syndrome (IBS). However, definite proof of an etiologic link between stress and gut motor dysfunction remains elusive, despite the large number of publications on this topic. A critical appraisal of methodology, use of controls, data interpretation, and significance of findings in the published literature is necessary to assess the present state of knowledge and to develop more meaningful studies in the future. This review attempts to summarize these perspectives.