Interaction of 5-fluorouracil with sodium carboxymethylcellulose

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1982 English Publisher:Springer Science and Business Media LLCJournal:Colloid & Polymer Science, volume 260, pages 511-513 (issn: 0303-402X, eissn: 1435-1536,

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Authors: K. Nishida; Y. Ando; M. Enomoto;

doi: 10.1007/bf01452998

Interaction of 5-fluorouracil with sodium carboxymethylcellulose

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Abstract

The interaction of an anticancer drug, 5-fluorouracil with sodium carboxymethylcellulose in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the standard molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. The standard molar change of enthalpy of 5-fluorouracil is about — 7 Kcal/mol with sodium carboxymethylcellulose. The enthalpy change is a considerably greater.

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Tokyo University of Agriculture and Technology
Japan

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