Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid
Copyright policy )Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid
This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN)-induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN-induced cholinergic toxicity by PIC may involve chelation of zinc.
- Queen's University Canada
Cerebral Cortex, Male, Excitatory Amino Acids, Quinolinic Acid, Choline O-Acetyltransferase, Rats, Rats, Sprague-Dawley, Zinc, Animals, Picolinic Acids, Chelating Agents
Cerebral Cortex, Male, Excitatory Amino Acids, Quinolinic Acid, Choline O-Acetyltransferase, Rats, Rats, Sprague-Dawley, Zinc, Animals, Picolinic Acids, Chelating Agents
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