Effect of interferon on Vero cells persistently infected with Sendai virus compared to Vero cells persistently infected with SSPE virus
Copyright policy )Effect of interferon on Vero cells persistently infected with Sendai virus compared to Vero cells persistently infected with SSPE virus
Persistent infections with Sendai and SSPE virus were established in Vero cells. Sequential passages of these cells were monitored by immunofluorescence and for their sensitivity to the antiviral and antiproliferative effects of interferon (IFN). The cells rapidly developed resistance to the antiviral effect of IFN as judged by the inability of IFN to inhibit the replication of exogenous Sindbis virus. This decrease was accompanied by a reduction in the induction of the 2'-5' oligo A synthetase. Both cell lines were resistant to the antiproliferative effect of IFN. A decrease or absence of IFN receptors on the surface of the cells was not found to be the cause of their resistance to IFN.
- National Institute of Virology India
- University of the Witwatersrand South Africa
Eukaryotic Initiation Factor-2, Proteins, Drug Resistance, Microbial, Virus Replication, Parainfluenza Virus 1, Human, Peptide Initiation Factors, SSPE Virus, Interferon Type I, 2',5'-Oligoadenylate Synthetase, Animals, Sindbis Virus, Phosphorylation, Receptors, Immunologic, Protein Kinases, Vero Cells, Cell Division, Receptors, Interferon
Eukaryotic Initiation Factor-2, Proteins, Drug Resistance, Microbial, Virus Replication, Parainfluenza Virus 1, Human, Peptide Initiation Factors, SSPE Virus, Interferon Type I, 2',5'-Oligoadenylate Synthetase, Animals, Sindbis Virus, Phosphorylation, Receptors, Immunologic, Protein Kinases, Vero Cells, Cell Division, Receptors, Interferon
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!