A serological comparison of bovine coronavirus strains

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1989 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 104, pages 241-248 (issn: 0304-8608, eissn: 1432-8798,

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Authors: El-Ghorr, A. A.; Snodgrass, D. R.; Scott, F. M. M.; Campbell, I.;

doi: 10.1007/bf01315546

pmid: 2650657

pmc: PMC7086754

A serological comparison of bovine coronavirus strains

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Abstract

Two bovine coronavirus (BCV) strains from diarrheic calf faeces were adapted to grow in HRT 18 cells and compared in immunofluorescence (IF), haemagglutination inhibition (HAI) and neutralisation (NT) tests with three other strains of BCV and a human coronavirus (HCV) strain obtained from other laboratories. Polyclonal antisera against these 6 viruses were raised in rabbits. No significant differences between viruses were detected by IF. In the HAI test the HCV strain was distinguishable from the 5 BCV strains and serological variation between the BCV strains was shown. HCV could be distinguished by NT test, but all BCV isolates were similar. Two monoclonal antibodies prepared against one of the BCV strains distinguished HCV in all three assays, and detected varying relationships between BCV strains.

Related Organizations

MOREDUN RESEARCH INSTITUTE
United Kingdom

Keywords

Virus Cultivation, Coronaviridae, Immune Sera, Antibodies, Monoclonal, Fluorescent Antibody Technique, Hemagglutination Inhibition Tests, Antibodies, Viral, Original Papers, Neutralization Tests, Animals, Humans, Cattle

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