Rimantadine hydrochloride blocks the second step of influenza virus uncoating

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1980 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 66, pages 275-282 (issn: 0304-8608, eissn: 1432-8798,

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Authors: A G, Bukrinskaya; N K, Vorkunova; R A, Narmanbetova;

doi: 10.1007/bf01314742

pmid: 7447705

Rimantadine hydrochloride blocks the second step of influenza virus uncoating

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Abstract

Two steps of influenza virus A/WSN uncoating in MDCK cells are described. The products of the first step are cores which accumulate in the nuclear-associated cytoplasm. The products of the second step are ribonucleoproteins which penetrate the nuclei. Rimantadine blocks the second step without interfering with the first one.

Related Organizations

Academy of Medical Sciences
United Kingdom

Keywords

Cell Nucleus, Cytoplasm, Adamantane, Cell Line, Viral Proteins, Dogs, Rimantadine, Ribonucleoproteins, Influenza A virus, Animals, Adsorption

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